The slave ship Lady Rachel left the African coast carrying enslaved Africans toward Antigua and Barbuda. About 280 people had been taken aboard.

Vessel: Lady Rachel; flag: Great Britain; rig: Ship; estimated standardized tonnage: 123.4. People recorded in connection with the voyage: Investor: Royal African Company; Captain: Lansdell, Charles; Investor: Lansdell, Charles. The voyage began at London on 20 July 1721. Principal recorded place where captives were acquired: Cape Coast Castle (Gold Coast). Principal recorded disembarkation place: Saint John (Antigua). Recorded duration of the captives' Atlantic crossing: 80 days. Estimated mortality during the crossing: 14.0%. Recorded outcome: Voyage completed as intended.