The slave ship Reine d'Espagne left the African coast carrying enslaved Africans toward Haiti. About 343 people had been taken aboard.

Vessel: Reine d'Espagne; flag: France; estimated standardized tonnage: 321.1. People recorded in connection with the voyage: Investor: Leclerc de Bicourt; Captain: Lemarcant. The voyage began at Saint-Malo on 8 August 1721. Principal recorded place where captives were acquired: Whydah, Ouidah (Bight of Benin). Principal recorded disembarkation place: Léogane. Recorded duration of the captives' Atlantic crossing: 76 days. Estimated mortality during the crossing: 16.0%. Recorded outcome: Voyage completed as intended.