The slave ship General Sampaio departed on a transatlantic slave-trading voyage that would carry enslaved Africans to Brazil.

Vessel: General Sampaio; flag: Portugal / Brazil; rig: Bergantim; estimated standardized tonnage: 187. People recorded in connection with the voyage: Investor: Cunha, Manoel Gomes; Captain: Ferreira, Joaquim Francisco Xavier. The voyage began at Lisbon on 11 September 1821. Principal recorded place where captives were acquired: Luanda (West Central Africa and St Helena). Principal recorded disembarkation place: Rio de Janeiro. Recorded duration of the captives' Atlantic crossing: 35 days. Estimated mortality during the crossing: 24.0%. Recorded outcome: Voyage completed as intended.