The slave ship General Isidro left the African coast carrying enslaved Africans toward Uruguay. About 481 people had been taken aboard.

Vessel: General Isidro; flag: Portugal / Brazil; rig: Fragata; estimated standardized tonnage: 300. People recorded in connection with the voyage: Captain: Almeida, Manoel Pedro de; Investor: Monteiro, Joaquim do Rosário. Principal recorded place where captives were acquired: Mozambique (East Africa and Indian Ocean islands). Principal recorded disembarkation place: Montevideo. Estimated mortality during the crossing: 36.0%. Recorded outcome: Returned direct to Africa after bringing enslaved people to the Americas.