The slave ship Two Sisters left the African coast carrying enslaved Africans toward Guyana. About 180 people had been taken aboard.

Vessel: Two Sisters; flag: Great Britain; rig: Brig; estimated standardized tonnage: 133. People recorded in connection with the voyage: Captain: Begg, William; Investor: Begg, William; Captain: Mill, John; Investor: Mill, John; Investor: Shand, Charles; Captain: Irving, George; Investor: Irving, George; Captain: Sinclair, John. The voyage began at Liverpool on 19 November 1800. Principal recorded place where captives were acquired: Windward Coast (Nunez - Assini) (Other Africa). Principal recorded disembarkation place: Demerara. Recorded outcome: Voyage completed as intended.