The slave ship Santíssimo Sacramento e Todos os Santos left the African coast carrying enslaved Africans toward Brazil. About 305 people had been taken aboard.

Vessel: Santíssimo Sacramento e Todos os Santos; flag: Portugal / Brazil; rig: Curveta. People recorded in connection with the voyage: Captain: Reinão, Jerônimo; Investor: Companhia Geral de Pernambuco e Paraíba. The voyage began at Pernambuco, place unspecified on 26 February 1781. Principal recorded place where captives were acquired: Luanda (West Central Africa and St Helena). Principal recorded disembarkation place: Pernambuco, place unspecified. Estimated mortality during the crossing: 10.0%. Recorded outcome: Voyage completed as intended.