The slave ship Saint John departed on a transatlantic slave-trading voyage that would carry enslaved Africans to Puerto Rico.

Vessel: Saint John; flag: Great Britain; rig: Ship; estimated standardized tonnage: 182.3. People recorded in connection with the voyage: Investor: Barber, Miles; Captain: Clifton, John. The voyage began at Liverpool on 14 November 1766. Principal recorded place where captives were acquired: West Central Africa and St Helena, port unspecified. Principal recorded disembarkation place: Puerto Rico, port unspecified. Estimated mortality during the crossing: 4.0%. Recorded outcome: Voyage completed as intended.