The slave ship Saint Domingo left the African coast carrying enslaved Africans toward Barbados. About 380 people had been taken aboard.

Vessel: Saint Domingo; flag: Great Britain; rig: Ship; estimated standardized tonnage: 269.3. People recorded in connection with the voyage: Investor: Campbell, George (Sr); Captain: Erskine, Robert; Investor: Erskine, Robert; Investor: Heys. The voyage began at Liverpool on 16 November 1765. Principal recorded place where captives were acquired: Cape Mount (Cape Grand Mount) (Windward Coast). Principal recorded disembarkation place: Barbados, place unspecified. Estimated mortality during the crossing: 33.0%. Recorded outcome: Voyage completed as intended.