The slave ship Duke of Argyle left the African coast carrying enslaved Africans toward Antigua and Barbuda. About 156 people had been taken aboard.

Vessel: Duke of Argyle; flag: Great Britain; rig: Snauw; estimated standardized tonnage: 182.3. People recorded in connection with the voyage: Investor: Manesty, Joseph; Investor: Hutchinson, Robert; Investor: Lessley, Andrew; Captain: Newton, John. The voyage began at Liverpool on 11 August 1750. Principal recorded place where captives were acquired: Windward Coast, place unspecified. Principal recorded disembarkation place: Saint John (Antigua). Estimated mortality during the crossing: 6.0%. Recorded resistance: Insurrection planned, but thwarted. Recorded outcome: Voyage completed as intended.