The slave ship Guillaume left the African coast carrying enslaved Africans toward Martinique. About 315 people had been taken aboard.

Vessel: Guillaume; flag: France; estimated standardized tonnage: 365.3. People recorded in connection with the voyage: Captain: Tessier, Pierre; Investor: Grou, Guillaume; Captain: Bichon, Joseph. The voyage began at Nantes on 6 October 1749. Principal recorded place where captives were acquired: Epe (Bight of Benin). Principal recorded disembarkation place: Martinique, place unspecified. Recorded duration of the captives' Atlantic crossing: 157 days. Estimated mortality during the crossing: 29.0%. Recorded outcome: Condemned - Americas after disembarkation.