The slave ship Hamilton left the African coast carrying enslaved Africans toward Jamaica. About 212 people had been taken aboard.

Vessel: Hamilton; flag: Great Britain; estimated standardized tonnage: 85.3. People recorded in connection with the voyage: Investor: Royal African Company; Captain: Buchanan, Jno. The voyage began at London on 25 October 1721. Principal recorded place where captives were acquired: Anomabu (Gold Coast). Principal recorded disembarkation place: Jamaica, place unspecified. Recorded duration of the captives' Atlantic crossing: 94 days. Estimated mortality during the crossing: 6.6%. Recorded outcome: Voyage completed as intended.