The slave ship Margaret left the African coast carrying enslaved Africans toward Antigua and Barbuda. About 265 people had been taken aboard.

Vessel: Margaret; flag: Great Britain; estimated standardized tonnage: 85.3. People recorded in connection with the voyage: Investor: Royal African Company; Captain: Barham, Samuel; Investor: Barham, Samuel; Captain: Anderson, William; Captain: Owen, John. The voyage began at London on 17 October 1721. Principal recorded place where captives were acquired: Bight of Benin, place unspecified. Principal recorded disembarkation place: Saint John (Antigua). Recorded duration of the captives' Atlantic crossing: 74 days. Estimated mortality during the crossing: 23.0%. Recorded outcome: Voyage completed as intended.