The slave ship Greyhound Sloop left the African coast carrying enslaved Africans toward Barbados. About 120 people had been taken aboard.

Vessel: Greyhound Sloop; flag: Great Britain; rig: Sloop; estimated standardized tonnage: 51. People recorded in connection with the voyage: Investor: Royal African Company; Captain: Powis, William. The voyage began at London on 4 February 1721. Principal recorded place where captives were acquired: Whydah, Ouidah (Bight of Benin). Principal recorded disembarkation place: Barbados, place unspecified. Recorded duration of the captives' Atlantic crossing: 53 days. Estimated mortality during the crossing: 11.0%. Recorded outcome: Returned direct to Africa after bringing enslaved people to the Americas.