The slave ship Angel de la Guarda departed on a transatlantic slave-trading voyage that would carry enslaved Africans to Venezuela.

Vessel: Angel de la Guarda; rig: Filibote; estimated standardized tonnage: 120. People recorded in connection with the voyage: Investor: Andrews, Antonio; Investor: Fernandez de Fonseca, Miguel; Captain: Brito, Enrique de; Captain: Antonio Andrés. The voyage began at San Lucar on 13 October 1619. Principal recorded place where captives were acquired: Luanda (West Central Africa and St Helena). Principal recorded disembarkation place: La Guaira. Estimated mortality during the crossing: 8.6%.