The slave ship Santana e S Domingos left the African coast carrying enslaved Africans toward Brazil. About 216 people had been taken aboard.

Vessel: Santana e S Domingos; flag: Portugal / Brazil; rig: Galera. People recorded in connection with the voyage: Investor: Companhia Geral do Grão Pará e Maranhão; Captain: Leão, José das Neves; Investor: Leão, José das Neves. The voyage began at Lisbon on 21 October 1776. Principal recorded place where captives were acquired: Bissau (Senegambia and offshore Atlantic). Principal recorded disembarkation place: Pará. Estimated mortality during the crossing: 5.0%. Recorded outcome: Voyage completed as intended.