The slave ship Seine left the African coast carrying enslaved Africans toward Haiti. About 458 people had been taken aboard.

Vessel: Seine; flag: France; estimated standardized tonnage: 321.1. People recorded in connection with the voyage: Captain: Laragon, Thomas; Investor: Michel; Investor: Grou. The voyage began at Nantes on 30 August 1749. Principal recorded place where captives were acquired: Whydah, Ouidah (Bight of Benin). Principal recorded disembarkation place: Port-au-Prince. Recorded duration of the captives' Atlantic crossing: 131 days. Estimated mortality during the crossing: 9.0%. Recorded outcome: Voyage completed as intended.