📅 11 January 1922
The fourteen-year-old patient was given a first pancreatic extract injection in Toronto.
📅 11 January 1922
The initial extract had only limited effect and caused a local reaction; a successful improved treatment followed later.
📅 11 January 1922
Leonard Thompson was the first human recipient in this Toronto research program.
📅 11 January 1922
The 11 January trial should not be confused with the more effective purified extract given on 23 January.
📅 23 January 1922
After the earlier limited-response injection, a preparation purified by Collip produced a marked improvement.
📅 23 January 1922
The second series of injections substantially reduced symptoms and biochemical evidence of diabetes.
📅 23 January 1922
Collip’s chemistry helped turn an experimental extract into a useful clinical treatment.
📅 23 January 1922
The achievement involved the patient and researchers Banting, Best, Collip and Macleod.
