Historical Organization
Toronto General Hospital
Toronto General Hospital
Details
Organization Timeline
Leonard Thompson receives an early insulin extract
📅 11 January 1922The fourteen-year-old patient was given a first pancreatic extract injection in Toronto.
A diabetes treatment is tried in a hospital
📅 11 January 1922The initial extract had only limited effect and caused a local reaction; a successful improved treatment followed later.
A patient joins a landmark insulin experiment
📅 11 January 1922Leonard Thompson was the first human recipient in this Toronto research program.
First insulin injection is distinct from first success
📅 11 January 1922The 11 January trial should not be confused with the more effective purified extract given on 23 January.
Thompson receives a more purified insulin extract
📅 23 January 1922After the earlier limited-response injection, a preparation purified by Collip produced a marked improvement.
Insulin treatment demonstrates clinical benefit
📅 23 January 1922The second series of injections substantially reduced symptoms and biochemical evidence of diabetes.
James Collip’s purification changes the result
📅 23 January 1922Collip’s chemistry helped turn an experimental extract into a useful clinical treatment.
A multi-person Toronto team advances diabetes care
📅 23 January 1922The achievement involved the patient and researchers Banting, Best, Collip and Macleod.